منابع مشابه
The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences.
BACKGROUND As the prevalence of adiposity soars in both developed and developing nations, appreciation of the close links between obesity and disease increases. The strong relationships between excess adipose tissue and poor health outcomes, including cardiovascular disease, diabetes, and cancer, mandate elucidation of the complex cellular, hormonal, and molecular pathophysiology whereby adipos...
متن کاملAdipocyte cholesterol balance in obesity
Submitted by Soazig Le Lay on Tue, 01/27/2015 10:41 Titre Adipocyte cholesterol balance in obesity. Type de publication Article de revue Auteur Le Lay, Soazig [1], Ferré, Pascal [2], Dugail, Isabelle [3] Editeur Portland Press Type Article scientifique dans une revue à comité de lecture Année 2004 Langue Anglais Date 02/2004 Pagination 103-6 Volume 32 Titre de la revue Biochemical Society Trans...
متن کاملAdipocyte cholesterol balance in obesity.
Adipose tissue is specialized in the storage of energy in the form of triacylglycerol. Within the fat cell, triacylglycerols are found in a well-defined structural compartment called the lipid droplet, which occupies the vast majority of the fat cell volume. However, many other lipids are present in the lipid droplet. These include sterols, carotenoids, cholecalciferol and lipophilic toxic poll...
متن کاملAdipocyte metabolism and obesity.
Adipose tissue metabolism exerts a profound impact on whole-body metabolism. We review how fuel partitioning between adipocytes and other tissues affects insulin signaling pathways. We discuss the role of adipose tissue inflammation in adipocyte metabolism and whole-body insulin sensitivity. Finally, we mention the role of adipokines in autocrine and paracrine signaling.
متن کاملHO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets
Background. Fructose metabolism is an unregulated metabolic pathway and excessive fructose consumption is known to activate ROS. HO-1 is a potent antioxidant gene that plays a key role in decreasing ROS and isoprostanes. We examined whether the fructose-mediated increase in adipocyte dysfunction involves an increase in isoprostanes and that pharmacological induction of HO-1 would decrease both ...
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ژورنال
عنوان ژورنال: Endocrine Abstracts
سال: 2013
ISSN: 1479-6848
DOI: 10.1530/endoabs.32.p801